After Thursday saw them come from two goals down on aggregate to beat FC Midtjylland 5-1 on the night and 6-3 over two legs, Louis van Gaal's men have been rewarded with an all-Premier League affair against their old rivals as they pursue what could be an unlikely route into Champions League qualification.
The two teams have played each other twice in the English top flight this season, with United winning both games, though the Red Devils have only three more points to their name than Jurgen Klopp's side.
There could well be only one of the three English teams left standing after the ties are done as Tottenham have drawn German giants Borussia Dortmund in one of the trickier fixtures.
Spain also sees a single-country matchup as Athletic Bilbao will take on Gary Neville's Valencia side, while holders Sevilla were paired with final hosts Basel.
| Shakhtar Donetsk | vs | Anderlecht |
| Basel | vs | Sevilla |
| Villarreal | vs | Bayer Leverkusen |
| Athletic Bilbao | vs | Valencia |
| Liverpool | vs | Manchester United |
| Sparta Prague | vs | Lazio |
| Borussia Dortmund | vs | Tottenham |
| Fenerbahce | vs | Braga |
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